Vitamin D and polycystic ovary syndrome: an integrating review

  • Ione Maria Ribeiro Soares Lopes
  • Caroliny Gonçalves Rodrigues Meireles Universidade Federal do Piauí
  • Iarlla Silva Ferreira
  • Nadya dos Santos Moura
  • Francisca Diana da Silva Negreiros
  • Alice Maria Correia Pequeno


Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrinopathyin women of reproductive age. It causes a metabolic syndrome characterized by insulin resistance, hyperinsulinemia, and dyslipidemia. Vitamin D deficiency and its association with PCOS still represents a controversial subject in the literature.

Objective: In this context, this study aimed to understand the association between polycystic ovary syndrome and vitamin D deficiency, and how it occurs.

Method: It was an integrative review conducted in the PubMed, Scopus, LILACS, and CINAHL databases from August 2016 to January 2017, with a sample of 7 articles analyzed in their entirety.

Results: The evidences according to the studies conducted and the conclusions they identified. 

Conclusions: It was concluded that we cannot yet assume that vitamin D deficiency contributes to the pathogenesis of PCOS, nor that the syndrome causes vitamin D deficiency, since the studies are controversial and there is a need for research with higher levels of evidence to clarify these doubts.


1.Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, et al. Consensus on womens's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM- Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril. 2012; 97(1):28-38.
2. Scott D, Joham A, Teede H, Gibson-Helm M, Harrison C, Cassar Set al. Associations of vitamin D with inter- and intra-muscular adipose tissue and insulin resistance in women with and without polycystic ovary syndrome. Nutrients. 2016; 8(12): 774.
3. Asemi Z, Foroozanfard F, Hashemi T, Bahmani F, Jamilian M, Esmaillzadeh A. Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome. Clin Nutr. 2015; 34(4):586-92.
4. Faria FR, Gusmão LS, Faria ER, Gonçalves VSS, Cecon RS, Franceschini SCC et al. Síndrome do ovário policístico e fatores relacionados em adolescentes de 15 a 18 anos. Rev Assoc Med Bras.  2013;  59(4):341-6.
5. Shahrokhi SZ, Ghaffari F, Kazerouni F. Role of vitamin D in female reproduction. Clin Chim Acta. 2016;455:33-8.
6. Raja-Khan N, Shah J, Stetter CM, Lott ME, Kunselman AR, Dodson WCet al. High-dose vitamin D supplementation and measures of insulin sensitivy in polycystic ovary syndrome: a randomized, controlled pilot trial. Fertil Steril. 2014; 101(6):1740-6.
7. Gallea M, Granzotto M, Azzolini S, Faggian D, Mozzanega B, Vettor Ret al. Insulin and body weight but not hyperandrogenism seem involved in seasonal serum 25-OH-vitamin D3 levels in subjects affected by PCOS. Gynecol Endocrinol. 2014; 30(10):739-45.
8. Faraji R,Sharami SH,Zahiri Z,Asgharni M,Kazemnejad E,Sadeghi S. Evaluation of relation between anthropometric indices and vitamin D Concentrations in women with polycystic ovarian syndrome. J Family Reprod Health. 2014; 8(3):123-9.
9. Galvão CMG,Mendes KDS,Silveira RCCP. Revisão integrativa: método de revisão para sintetizar as evidências disponíveis na literatura. In: Brevidelli MM,Sertório SCM. TCC – Trabalho de conclusão de curso: guia prático para docentes e alunos da área da saúde. São Paulo: Iátria; 2010, p. 105-25.
10. Evans D. Overview of methods. In: Webb C,Roe B, editors. Reviewing reserach evidence for nursing practice: systematic reviews. Oxford: Blackwell Publishing; 2007, p. 149-156.
11. Jia XZ, Wang YM, Zhang N, Guo LN, Zhen XL, Li H et al. Effect of vitamin D on clinical and biochemical parameters in polycystic ovary syndrome women: a meta-analysis. J Obstet Gynaecol Res. 2015; 41(11):1791-802.
12. Sahin S, Eroglu M, Selcuk S, Turkgeldi L, Kozali S, Davutoglu S et al. Intrinsic fators rather than vitamin D deficiency are related to insulin resistance in lean women with polycystic ovary syndrome. Eur Rev Med Pharmacol Sci. 2014; 18(19):2851-6.
13. Kim JJ, Choi YM, Chae SJ, Hwang KR, Yoon SH, Kim MJet al. Vitamin D deficiency in women with polycystic ovary syndrome. Clin Exp Reprod Med. 2014; 41(2):80-5.
14. Mahmoudi T, Majidzadeh-A K, Farahani H, Mirakhorli M, Dabiri R, Nobakht Het al. Association of vitamin D receptor gene variants with polycystic ovary syndrome: a case control study. Int J Reprod Biomed (Yazd). 2015; 13(12):793-800.
15. Moini A, Shirzad N, Ahmadzadeh M, Hosseini R, Hosseini L, Sadatmahalleh SJ. S. Comparison of 25-hydroxyvitamin D and calcium levels between polycystic ovarian syndrome and normal women. Int J Fertil Steril. 2015; 9(1):1-8.
16. Wehr E, Pilz S, Schweighofer N, Giuliani A, Kopera D, Pieber TRet al. Vitamin D deficiency in association with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol. 2009; 161(4):575-82.
17. He C, Lin Z, Robb SW, Ezeamama AE. Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis. Nutrients. 2015; 7(6):4555-77.
18. Drummond JP. Fundamentos da medicina baseada em evidências: teoria e prática. 2ª ed. São Paulo: Editora Atheneu; 2014.
19. Wehr E, Trummer O, Giuliani A, Gruber H, Pieber T, Obermayer-Pietsh B. Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency un polycystic ovary syndrome. Eur J of Endocrinol. 2011;164: 741-749.
20. Tsakova AD, Gateva AT, Kamenov ZA. 25(OH) vitamin D levels in premenopausal women with polycystic ovary syndrome and/or obesity. Int J Vitam Nutr Res. 2012; 82(6):399-404.
21. Anagnostis P, Karras S, Goulis DG. Vitamin D in human reproduction: a narrative review. Int J Clin Pract. 2013; 67(3):225-35.
22. Nestler JE, Reilly ER, Cheag KI, Bachmann LM, Downs RW. A pilot study: effects of decreasing sérum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome. Trans Am Clin Climatol Assoc. 2012; 123:209-20.
23. Yildizhan R, Kurdoglu M, Adali E, Kolusari A, Yildizhan B, Sahin HG et al. Serum 25-hydroxyvitaminD concentrations in obese and nonobese women with polycystic ovary syndrome. Arch Gynecol Obstet. 2009; 280(4):559-63.
24. Krul-Poel YH, Snackey C, Louwers Y, Lips P, Lambalk CB, Laven JS et al. The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic rewien. Eur J Endocrinol. 2013; 169(6):853-65.
25. Pal L, Berry A, Coraluzzi L, Kustan E, Danton C, Shaw J et al. Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome. Gynecol Endocrinol. 2012; 28(12):965-8.
26. Muscogiuri G, Mitri J, Mathieu C, Badenhoop K, Tamer G, Orio Fet al. Mechanisms in endocrinology: Vitamin D as a potencial contributor in endrocine health and disease. Eur J Endocrinol. 2014; 171(3):101-10.
How to Cite
LOPES, Ione Maria Ribeiro Soares et al. Vitamin D and polycystic ovary syndrome: an integrating review. International Archives of Medicine, [S.l.], v. 10, apr. 2017. ISSN 1755-7682. Available at: <>. Date accessed: 12 nov. 2019. doi:
Obstetrics & Gynecology