Endometrial osseous metaplasia: Presentation of two rare cases related with infertility, and their hysteroscopic approaching
Objective: To present two cases of patients diagnosed of endometrial osseous metaplasia related with infertility and their hysteroscopic approaching.
Design: Case report.
Setting: Two clinical cases diagnosed and treated at Institutional University Hospital. Patients: Two premenopasual women diagnosed and treated in our Center.
Interventions: Transvaginal ultrasound scan, diagnostic hysteroscopy and hysteroscopic removal of bone fragments. Main Outcome Measures: Ultrasound scan during further clinical follow up.
Results: Both patients underwent a diagnostic hysteroscopy, and removal of all the bone fragments with total resolution of their pathology.
Conclusions: Endometrial osseous metaplasia is a rare pathology that should be suspected in patients with a history of secondary infertility, several miscarriages and curettages, that present with an ultrasound image compatible with an intrauterine device. Hysteroscopic approach is the best diagnostic and therapeutic option.
Key words: Endometrial osseous metaplasia, bony intrauterine tissue, miscarriage, infertility, hysteroscopy, unadverted intrauterine device.
2. Thaler H. Uberlebendes fotales knorpelgewebe in der uterushohel nach abortus. Zentralbl agynekol 1923;46:1784-7.
3. De Brux J, Palmer R, Anoub-Despois H. Les ossification de l’endometre. Gynecol Obstet 1956;55:494.
4. Patil SB, Narchal S, Paricharak DG, More SS. Endometrial Osseous Metaplasia: Case Report with Literature Review. Annals of Medical and Health Sciences Research, Nov 2013, Vol 3, Sup 1.
5. Bahceci M, Cem L. Osseous metaplasma of the endometrium: a rare case of infertility and its hysteroscopic management. Human Reprod 1996; 11:2537-39.
6. Bedaiwy MA, Goldberg JM, Biscotti CH. Recurrent osseous metaplasia of the cervix after loop electrosurgical excision. Obstet Gynecol 2001;98:968-70.
7. Elford K, Claman P:Novel treatment of a patient with secondary infertility due to retaines fetal bone. Fertil Steril 2003;79:1028-1030.
8. Verstraete JP, Adnet JJ, Wahl P. Osteogenic metaplasia or residual embryonic endometrial ossification?. J. Gynecol Obstet Biol Reprod (Paris) 1984;13:425-31.
9. Torne A, Jou P, Pagano R, Sánchez I, Ordi J, Vanrell JA. Endometrial ossification succesfully treated by hysteroscopic resection. Eur J Obstet Gynecol Reprod Biol 1996;66:75-7.
10. Hsu C. Endometrial ossification. Br J Obstet Gynaecol 1975; 82:836-9.
11. Ejeckam GC, Hasled F, Ahamad R, Azadeh B. Endometrial Ossifiaction. Trop Georg Med 1991;43:314-6.
12. Mannu GS1, Ahmed F1, Cunnick G1, Mungalsingh N2. Bone formation within breast abscess. BMJ Case Rep. 2014 Sep 22;2014.
13. Joshi M, Remoundos DD, Ahmed F, Rees G, Cunnick G. An unusual breast lump: osseous metaplasia. BMJ Case Rep. 2013; Published online 2013 Feb 4.
14. Markert E1, Gruber-Moesenbacher U, Porubsky C, Popper HH. Lung osteoma--a new benign lung lesion. Virchows Arch. 2006 Jul;449(1):117-20.
15. Nogales FF, Gómez Morales M, Raymundo C, Aguilar D. Benign heterologous tissue components associated with endometrial carcinoma. Int J Gynecol Pathol 1982;1:286-91.
16. Lewis V, Khan-Dawood F, King M, Beckham C, Dawood My. Retention of fetal bone increases menstrual prostaglandins. Obstet Gynecol 1990;75:561-3.
17. Marcus S, Bhattacharya J, Williams G, Brinsden P, Hamou J. Endometrial ossification: a case of secondary infertility. Report of two cases. Am J Obstet Gynecol 1994;170:1381-3.
18. Tsai MC, Arunamata A, Tristan S, Randall HW. Endometrial osseous metaplasia mimicking retained intrauterine device. J Reprod Med 2008;53:877-880.
19. Coccia ME, Becattini C, Bracco GL, Scarselli G. Ultrasound-guided hysteroscopic management of endometrial osseous metaplasia. Ultrasound Obstet Gynecol 1996;66:75-7.
20. Pace S, Torcia F, Palazzetti PL, Piazze JJ, Cipriano L, Pachi A. Succesful diagnostic and surgical hysteroscopy for endometrial ossification. Clin Exp Obstet Gynecol 2001;28:24-5.
21. Polat I, Sahin O, Yildirim G, Karaman E, Erim A, Tekirdag AI, Osseous metaplasia of the cervix and endometrium: a case of secondary infertility. Fertility and Sterility, 2011;95,7:2434.e1-e4.
Copyright policies & self-archiving
We are a RoMEO green journal.
Author's Pre-print: author can archive pre-print (ie pre-refereeing)
Author's Post-print: author can archive post-print (ie final draft post-refereeing)
Publisher's Version/PDF: author can archive publisher's version/PDF
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access and Benefits of Publishing Open Access).
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.
Articles are published Under License of Creative Commons Attribution 4.0 License ©