Effects of Andiroba oil (Carapa guianensis) on wound healing in alloxan-diabetic rats

  • Bruna Angelina Alves de Souza
  • Leandro Augusto Braga
  • Luiz Renato Oliveira Lopes
  • Rubens Fernando Gonçalves Ribeiro Júnior State University of Pará
  • Laiane Nazaré Silva do Nascimento
  • Lainy Carollyne da Costa Cavalcante
  • Andrew Moraes Monteiro
  • Rodrigo Paracampo Couteiro
  • Edson Yuzur Yasojima
  • Moisés Hamoy


Purpose: To evaluate wound healing in diabetic rats by using topic Andiroba oil (Carapa guianensis).

Methods: Six male, adult, Wistar rats were distributed into three groups: Sham group (wound treatment with distilled water); Collagenase group (treatment with collagenase ointment); and Andiroba group (wound treatment with Andiroba oil). The wound was evaluated considering the macroscopic and microscopic parameters.

Results: The results indicated differences in the healing of incisional wounds between treatments when compared to control group. Accelerated wound healing was observed in the group treated with Andiroba oil and Collagenase in comparison to control group, especially after the 14th day. Morphometric data confirmed the structural findings.

Conclusion: There was significant effect in topical application of Andiroba oil on wound healing in rats with induced diabetes.


Keywords: Medicinal plants. Diabetes Mellitus. Wound healing. Rats.


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How to Cite
ALVES DE SOUZA, Bruna Angelina et al. Effects of Andiroba oil (Carapa guianensis) on wound healing in alloxan-diabetic rats. International Archives of Medicine, [S.l.], v. 10, oct. 2017. ISSN 1755-7682. Available at: <http://imedicalsociety.org/ojs/index.php/iam/article/view/2733>. Date accessed: 18 sep. 2019. doi: https://doi.org/10.3823/2533.

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