Effects of Andiroba oil (Carapa guianensis) on wound healing in alloxan-diabetic rats
Purpose: To evaluate wound healing in diabetic rats by using topic Andiroba oil (Carapa guianensis).
Methods: Six male, adult, Wistar rats were distributed into three groups: Sham group (wound treatment with distilled water); Collagenase group (treatment with collagenase ointment); and Andiroba group (wound treatment with Andiroba oil). The wound was evaluated considering the macroscopic and microscopic parameters.
Results: The results indicated differences in the healing of incisional wounds between treatments when compared to control group. Accelerated wound healing was observed in the group treated with Andiroba oil and Collagenase in comparison to control group, especially after the 14th day. Morphometric data confirmed the structural findings.
Conclusion: There was significant effect in topical application of Andiroba oil on wound healing in rats with induced diabetes.
Keywords: Medicinal plants. Diabetes Mellitus. Wound healing. Rats.
2. Lipsky BA, Aragón-Sánchez J, Diggle M, Embil J, Kono S, Lavery L et al. IWGDF guidance on the diagnosis and management of foot infections in persons with diabetes. Diabetes Metab Res Rev. 2016 Jan;32 Suppl 1:45-74. doi: 10.1002/dmrr.2699.
3. Powers JG, Higham C, Broussard K, Phillips TJ. Wound healing and treating wounds: Chronic wound care and management. J Am Acad Dermatol. 2016 Apr;74(4):607-25. doi: 10.1016/j.jaad.2015.08.070.
4. Burlando B, Cornara L. Revisiting Amazonian Plants for Skin Care and Disease. Cosmetics 2017, 4(3), 25. doi:10.3390/cosmetics4030025.
5. Higuchi K, Miyake T, Ohmori S, Tani Y, Minoura K, Kikuchi T et al. Carapanosins A-C from Seeds of Andiroba (Carapa guianensis, Meliaceae) and Their Effects on LPS-Activated NO Production. Molecules. 2017 Mar 22;22(3). doi: 10.3390/molecules22030502.
6. Ben Abdallah Kolsi R, Ben Gara A, Jardak N, Chaaben R, El Feki A, El Feki L et al. Inhibitory effects of Cymodocea nodosa sulphated polysaccharide on α-amylase activity, liver-kidney toxicities and lipid profile disorders in diabetic rats. Arch Physiol Biochem. 2015;121(5):218-27. doi: 10.3109/13813455.2015.1107588.
7. Gupta MP, Solis NG, Avella ME, Sanchez C. Hypoglycemic activity of Neurolaena lobata (L.) R. BR. J Ethnopharmacol. 1984 May;10(3):323-7. doi: 10.1016/0378-8741(84)90020-5.
8. Santos LOM, Simões MLPB, Machado APB, Matioski FGR, Endo PC, Gruen GR, et al. Effect of somatotropin on skin wound healing in rats. Acta Cir. Bras. 2002 Jul-Aug; 17(4):220-224. doi: 10.1590/S0102-86502002000400004.
9. Peter FW, Li-Peuser H, Vogt PM, Muehlberger T, Homann HH, Steinau HU. The effect of wound ointments on tissue microcirculation and leucocyte behaviour. Clin Exp Dermatol. 2002 Jan;27(1):51-5. doi: 10.1046/j.0307-6938.2001.00937.x.
10. Marazzi M, Stefani A, Chiaratti A, Ordanini MN, Falcone L, Rapisarda V. Effect of enzymatic debridement with collagenase on acute and chronic hard-to-heal wounds. J Wound Care. 2006 May;15(5):222-7. doi: 10.12968/jowc.2006.15.5.26910.
11. Ostlie DJ, Juang D, Aquayo P, Pettiford-Cunningham JP, Erkmann EA, Rash DE, et al. Topical silver sulfadiazine vs collagenase ointment for the treatment of partial thickness burns in children: a prospective randomized trial. J Pediatr Surg. 2012 Jun;47(6):1204-7. doi: 10.1016/j.jpedsurg.2012.03.028.
12. Mekkes JR, Zeegelaar JE, Westerhof W. Quantitative and objective evaluation of wound debriding properties of collagenase and fibrinolysin/desoxyribonuclease in a necrotic ulcer animal model. Arch Dermatol Res. 1998 Mar;290(3):152-7. doi: 10.1007/s004030050281.
13. Tallis A, Motley TA, Wunderlich RP, Dickerson Jr JE, Waycaster C, Slade HB, et al. Clinical and economic assessment of diabetic foot ulcer debridement with collagenase: results of a randomized controlled study. Clin Ther. 2013 Nov;35(11):1805-20. doi: 10.1016/j.clinthera.2013.09.013.
14. Nayak BS, Vinutha B, Geetha B, Sudha B. Experimental evaluation of Pentas lanceolata flowers for wound healing activity in rats. Fitoterapia. 2005 Dec;76(7-8):671-5. doi: 10.1016/j.fitote.2005.08.007.
15. Lusby PE, Coombes A, Wilkinson JM. Honey: a potent agent for wound healing? J Wound Ostomy Continence Nurs. 2002 Nov;29(6):295-300. doi: 10.1067/mjw.2002.129073.
16. Simon A, Traynor K, Santos K, Blaser G, Bode U, Molan P. Medical honey for wound care-still the 'latest resort'? Evid Based Complement Alternat Med. 2009 Jun;6(2):165-73. doi: 10.1093/ecam/nem175.
17. Funck LG, Barrera-Arellano D, Block JM. Conjugated Linoleic Acid (Cla) And Its Relationship With Cardiovascular Disease And Associated Risk Factors. Arch Latinoam Nutr. 2006; 56(2).
18. Pareja B. Dermopharmacy: medicinal plants with aplications in dermatology and cosmetics. Folia Dermat Peruana. 1996 7(3/4):48-52.
19. Godoy JMP, Prado PA. Ácidos gordos essenciais enriquecidos com vitamina A, E e ácido linoleico como pensos em feridas crônicas. Rev Port Clin Geral. 2005 21:193-5.
20. Szentmihályi K, Vinkler P, Lakatos B, Illés V, Then M. Rose hip (Rosa canina L.) oil obtained from waste hip seeds by different extraction methods. Bioresour Technol. 2002 82(2): 195-201. doi: 10.1016/S0960-8524(01)00161-4.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright policies & self-archiving
We are a RoMEO green journal.
Author's Pre-print: author can archive pre-print (ie pre-refereeing)
Author's Post-print: author can archive post-print (ie final draft post-refereeing)
Publisher's Version/PDF: author can archive publisher's version/PDF
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access and Benefits of Publishing Open Access).
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.
Articles are published Under License of Creative Commons Attribution 4.0 License ©