Impact of prenatal antimicrobial treatment on fetal brain damage due to autogenous fecal peritonitis in Wistar rats: A Histomorphometric Study

  • Neylane Gadelha
  • Diego Gadelha Unifacisa
  • Alexandre Paz
  • Maria Cecilia Melo
  • Tharcia Kiara Oliveira
  • Carlos Brandt

Abstract

Purpose: To investigate brain neuronal density in newborn rats whose mothers were subjected to fecal peritonitis and compare findings between rats born to mothers treated and not treated with antimicrobials.


Methods: Peritonitis was induced with a 10% fecal suspension (4mL/kg) in 2 pregnant rats. Of these, 1 received antimicrobial treatment 24 hours after peritonitis induction: moxifloxacin and dexamethasone plus 2 mL of the inner bark of the Schinus terebinthifolius raddi extract. One pregnant rat underwent no intervention and served as a control.


Results: The newborn brains of rats born to mothers with fecal peritonitis were significantly smaller and of less firm consistency. Brain neuronal density was lower in the untreated group than in the control and treated groups (P<0.01).


Conclusions: Untreated peritonitis caused brain damage in the offspring, which was averted by effective early antimicrobial treatment. This approach may provide an early avenue for translation of such therapy in humans.


Keywords: peritonitis, brain injuries, rats

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Published
2017-10-19
How to Cite
GADELHA, Neylane et al. Impact of prenatal antimicrobial treatment on fetal brain damage due to autogenous fecal peritonitis in Wistar rats: A Histomorphometric Study. International Archives of Medicine, [S.l.], v. 10, oct. 2017. ISSN 1755-7682. Available at: <http://imedicalsociety.org/ojs/index.php/iam/article/view/2742>. Date accessed: 18 july 2018. doi: https://doi.org/10.3823/2528.
Section
Infectious Diseases

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